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the bone mineral density efficacy of fosamax 10 mg once daily in postmenopausal women, 44 to 84 years of age, with osteoporosis lumbar spine bone mineral density bmd of at least 2 standard deviations below the premenopausal mean was demonstrated in four double-blind, placebo-controlled clinical studies of two or three years duration.
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physicians should therefore be alert to any signs or symptoms signaling a possible esophageal reaction and patients should be instructed to discontinue fosamax and seek medical attention if they develop dysphagia, odynophagia, retrosternal pain or new or worsening heartburn.
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this is why fosamax is not recommended for people with a history of kidney problems.
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