The binding of colchicine to serum protein is quite low which is 39 -5 due to albumin, regardless of the concentration.
It is proficiently worthy to note that in spite of the unworkable side dreamer, therapeutic doses of colchicine are painlessly safe.
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If probenecid and colchicine is given with methotrexate, the dosage of methotrexate should be reduced and serum levels may need to be monitored.
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keep colchicine in its original container, tightly closed and out of reach of children.