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clozapine brand names clozaril and fazaclo was the first of many atypical antipsychotics, or, what are sometimes referred to as second generation neuroleptics, to be developed over the past many years.
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although it has not been established that there is an interaction between clozaril and benzodiazepines or other psychotropics, caution is advised when clozapine is initiated in patients taking a benzodiazepine or any other psychotropic drug.
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tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking clozaril, even if you do not think it is connected with the medicine.
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inform patients and caregivers clozaril is available only through a restricted program called the clozaril rems program designed to ensure the required blood monitoring, in order to reduce the risk of developing severe neutropenia.
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the mechanism of clozaril-induced agranulocytosis is unknown; nonetheless, the possibility that causative factors may interact synergistically to increase the risk and or severity of bone marrow suppression warrants consideration.
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